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Berberine , a plant alkaloid that lowers blood glucose and cholesterol through AMPK and is often called natures metformin, has no clinical evidence for cognition or neuroprotection, only animal work

Oral supplements may cause mild digestive discomfort in some individuals, while injectable forms may involve risks such as local irritation at the injection site or allergic reactions in certain cases

Ipamorelin is a Growth Hormone Releasing Peptide (GHRP), pentapeptide ( 5 amino acids), and ghrelin agonist

Altogether 84 patients reporting moderate to severe heartburn and regurgitation symptoms underwent control treatment (PPI + tap water) or experimental treatment (PPI + ERW) for 3 months